靶點(diǎn) RNA-seq 脂質(zhì)代謝 阿爾茨海默病 senaparib 艾瑪昔替尼 埃萬(wàn)妥單抗

①Nature：From target discovery to clinical drug development with human genetics

綜述：從靶點(diǎn)發(fā)現(xiàn)到人類遺傳學(xué)臨床藥物開(kāi)發(fā)

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DOI: 10.1038/s41586-023-06388-8

②Nature Communications：FAP106 is an interaction hub for assembling microtubule inner proteins at the cilium inner junction

FAP106是纖毛內(nèi)部連接組裝微管內(nèi)部蛋白(MIPs)的相互作用樞紐

DOI: 10.1038/s41467-023-40230-z

③Nature Communications：Coordinated single-cell tumor microenvironment dynamics reinforce pancreatic cancer subtype

通過(guò)單細(xì)胞RNA-seq的腫瘤微環(huán)境(TME)進(jìn)行表征揭示與胰腺導(dǎo)管腺癌(PDAC)表型相關(guān)的細(xì)胞類型和相互作用

DOI: 10.1038/s41467-023-40895-6

④Nature Communications：Neuronal ER-plasma membrane junctions couple excitation to Ca2+-activated PKA signaling

神經(jīng)元內(nèi)質(zhì)網(wǎng)(ER)和質(zhì)膜(PM)連接激活細(xì)胞內(nèi)Ca2+驅(qū)動(dòng)的非受體形式的蛋白激酶A （PKA）信號(hào)

DOI: 10.1038/s41467-023-40930-6

⑤Nature Communications：Hepatic SREBP signaling requires SPRING to govern systemic lipid metabolism in mice and humans

SPRING是小鼠和人類肝臟SREBP信號(hào)通路和全身脂質(zhì)代謝的核心組成部分

DOI: 10.1038/s41467-023-40943-1

⑥Nature Neuroscience：Efficacy and Safety of Dupilumab in Older Patients (Aged 80 Years and Above) with Atopic Dermatitis: A Prospective Study

浸潤(rùn)的CD8+T細(xì)胞在3D人類神經(jīng)免疫軸模型中加劇阿爾茨海默病(AD)的病理機(jī)制

DOI: 10.1038/s41593-023-01415-3

⑦聚腺苷二磷酸核糖聚合酶（PARP）抑制劑senaparib的新藥上市申請(qǐng)獲CDE受理，用于III-IV期上皮性卵巢癌、輸卵管癌或原發(fā)性腹膜癌

⑧JAK1抑制劑艾瑪昔替尼片（SHR0302）新適應(yīng)癥的上市申請(qǐng)獲CDE受理，推測(cè)申報(bào)適應(yīng)癥為活動(dòng)性強(qiáng)直性脊柱炎（AS）

⑨EGFR/c-Met雙抗藥物埃萬(wàn)妥單抗（Rybrevant）的補(bǔ)充上市申請(qǐng)獲FDA受理，聯(lián)合化療用于EGFR外顯子20插入突變、局部晚期或轉(zhuǎn)移性非小細(xì)胞肺癌

⑩PCSK9大環(huán)肽抑制劑MK-0616用于高膽固醇血癥的Ⅲ期臨床CORALreef首批受試者入組

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